The History of Whoo

Royal Regina line

The History of Whoo’s “Royal Regina” line (로얄 레지나) is an anti-aging skincare line created to address first signs of aging. The line is designed to support skin barrier function, revitalise complexion and promote skin regeneration.

Disclaimer: I personally translated the majority of facts and contents in this article from original Korean sources, so I kindly ask you to credit my work if you’re planning to use any of the information included in this guide.

Many concepts mentioned in this guide are based on Oriental Medicine principles, for a better understanding please refer to the introduction to Traditional Korean Medicine on this website. It’s important to stress out that there is no correspondence between Oriental Medicine organs and Western anatomy so capitalised names in this article shouldn’t be interpreted in the Western medical sense.

⬥ Recommended for:

  • First fine lines
  • Dull and fatigued skin
  • Impaired skin barrier function
  • Rough and uneven skin texture
  • Individuals in their 20s

Main Ingredients

Royal Iris Absolute™

Royal Iris Absolute™ is an innovative anti-aging ingredient derived from the roots of Iris Pallida, and meticulously processed to mitigate stress-related skin changes and enhance skin’s elasticity and resilience.

Iris species have been valued for their medicinal properties for centuries, across both Eastern and Western traditions. The rhizomes of various Iris species have been traditionally used to treat a wide range of ailments. Contemporary research supports these traditional uses, highlighting the potent biological activities of Iris extracts, including anti-inflammatory, antioxidant, and antimicrobial effects1.

Through innovative extraction techniques and rigorous research, the Whoo Oriental Medicine Skin Science Research Center has developed an ingredient that not only preserves the integrity of the iris’s beneficial compounds but also offers outstanding skin benefits.

Iris Pallida, the primary component of Royal Iris Absolute™, undergoes a cultivation period of 1,000 days, followed by another 1,000 days of maturation to ensure the plant develops a rich profile of beneficial compounds. The extraction of Iris Pallida is then carried out through a gentle, low-temperature extraction method to preserve the bioactive properties of the iris and ensuring that its full antioxidant potential is retained in the final ingredient.

The History of Whoo - Royal Iris Absolute

The History of Whoo’s research into Iris Pallida Extract revealed its ability to counteract the negative effects of cortisol on the skin. Their studies showed that Iris Pallida Extract can significantly restore the levels of procollagen type 1 and hyaluronic acid that are typically reduced due to stress-related cortisol secretion. Specifically, Iris Pallida Extract restored these levels by 106% and 31%, respectively. Additionally, the extract was found to inhibit the translocation of the glucocorticoid receptor within cells, a process crucial for cortisol’s damaging impact on the skin.

High-performance liquid chromatography analysis revealed that irigenin, an isoflavone in Iris Pallida Extract, was the key compound responsible for restoring collagen levels by 82%.

These results suggest that Iris Pallida Extract not only protects against cortisol-induced collagen and hyaluronic acid degradation but also promotes the synthesis of these vital components by modulating gene expression related to collagen and hyaluronic acid production2.

Royal Amino Repair™

Royal Amino Repair™ is a cutting-edge cosmetic ingredient designed to promote skin regeneration and fortify the skin’s natural barrier. This innovative ingredient is protected by a patent in Korea (number 102411385) and consists of a unique blend of two amino acids, Arginine and Glutamate.

The creation of Royal Amino Repair™ was inspired by an extensive analysis of over 500 traditional royal beauty remedies and medicinal herbs. Through big data analysis of these historical records, The History of Whoo research team identified Arginine and Glutamate as two of the most effective and frequently used amino acids. Initially, the researchers experimented with simple mixtures of these amino acids. However, subsequent investigations revealed that combining them into a eutectic mixture significantly enhanced their efficacy3.

The History of Whoo - Royal Amino Repair

A eutectic mixture is the combination of two or more substances in precise ratios to form a solution with a lower melting point than its individual components. This occurs when the substances interact in a way that disrupts the crystalline structure, reducing the energy needed to convert the mixture from solid to liquid.

In the case of Royal Amino Repair™, the eutectic mixture is formed by combining positively charged Arginine and negatively charged Glutamate. This specific combination interferes with the formation of solid crystals due to molecular interactions known as Van der Waals forces. By preventing crystallisation, the eutectic mixture maintains its liquid form, enhancing both its stability and effectiveness in skincare formulas.

To demonstrate the benefits of Royal Amino Repair™, The History of Whoo conducted rigorous experiments3. In one study, 20 female participants aged 25 to 45 applied a cream with Royal Amino Repair™ twice daily for eight weeks. The results showed a 29% increase in skin elasticity, confirming the ingredient’s significant impact on enhancing skin viscoelasticity.

In another experiment, the brand tested the wound healing efficacy of a 10 ppm Royal Amino Repair™ solution. The results showed a remarkable 92.2% wound healing rate, with microscopic images confirming extensive cell coverage in scratched areas.

These results surpassed treatments using individual amino acids or simple mixtures, highlighting the superior properties of Royal Amino Repair™.

Overall, Royal Amino Repair™ offers a wide range of skin benefits:

  • Skin Regeneration: Royal Amino Repair™ was shown to promote cell regeneration, enhancing the skin’s ability to heal and renew itself.
  • Wrinkle Alleviation: Royal Amino Repair™ was confirmed to enhance skin elasticity and promote collagen production, effectively reducing the appearance of wrinkles.
  • Pore Reduction: Royal Amino Repair™ effectively reduces the number of pores, leading to a smoother complexion.
  • Excellent Skin Permeability: The eutectic mixture used to formulate Royal Amino Repair™ shows excellent skin permeability, ensuring deeper and more effective absorption of the active ingredients.
  • Enhanced Stability: The eutectic mixture used to formulate Royal Amino Repair™ retains its stability even in weakly acidic or neutral environments, ensuring consistent efficacy.
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Royal Regina Energy Drop Treatment

Royal Regina Energetic Repair Serum

Royal Regina Energetic Recharging Cream

⬥ Recommended order of use

  • Royal Regina Energy Drop Treatment
  • Royal Regina Energetic Repair Serum
  • Royal Regina Energetic Recharging Cream
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Shop the Line

⬥ International retailers

  • n/a

⬥ South Korean retailers

Make sure to check out the Discount & Coupons page to access exclusive offers for major Korean skincare retailers.

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  1. Kim, J.-S., Lee, H.-J., Yoon, E.-J., Lee, H., Ji, Y., Kim, Y., Park, S.-J., Kim, J., & Bae, S. (2023). Protective effect of Iris germanica L. rhizome-derived exosome against oxidative-stress-induced cellular senescence in human epidermal keratinocytes. Applied Sciences, 13(21), 11681.
  2. Choo, J. H., Lee, H. G., Lee, S. Y., & Kang, N. G. (2023). Iris pallida extract alleviates cortisol-induced decrease in type 1 collagen and hyaluronic acid syntheses in human skin cells. Current Issues in Molecular Biology, 45(1), 353–363.
  3. LG H&H Co Ltd. (2021). 공융 혼합물을 포함하는 화장료 조성물 (Korean Patent No. 102411385). Korean Intellectual Property Office.

Source: LG Household & Health Care unless otherwise stated.
Words, Visuals: © 2024 Odile Monod unless otherwise stated.
You may not reproduce the above translation for commercial purposes without the express written consent of the author.

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